Production of butane-1,4-diol

ABSTRACT

Butane-1,4-diol is produced by converting allyl alcohol to an allyl t-alkyl or -cycloalkyl ether of the general formula: ##STR1## wherein R 1  and R 2  each, independently of the other, represent a C 1  to C 4  alkyl radical, and R 3  and R 4  each, independently of the other, represent a hydrogen atom or a C 1  to C 3  alkyl radical, or wherein R 1  represents a C 1  to C 4  alkyl radical, R 2  and R 3  together with the carbon atoms to which they are attached form a 5-membered or 6-membered cycloaliphatic ring, and R 4  represents a hydrogen atom or a C 1  to C 3  alkyl radical, followed by reacting resulting compound of formula (III) under hydroformylation conditions with carbon monoxide and hydrogen in the presence of a hydroformylation catalyst to form a corresponding aldehyde-ether of the general formula: ##STR2## reducing resulting aldehyde-ether of the general formula (II) to form a corresponding hydroxy-ether of the general formula: ##STR3## and cleaving resulting hydroxy-ether of the general formula (II) to give butane-1,4-diol. Typically R 1  and R 2  each represent a methyl group while R 3  and R 4  each represent a hydrogen atom. The alkene of the general formula: ##STR4## released upon cleavage of the hydroxy-ether of formula (II) can be recycled for reaction with further allyl alcohol to form a further quantity of the ether of the general formula (III).

This is a continuation of application Ser. No. 321,087 filed Nov. 13, 1981, which was a continuation of application Ser. No. 139,570 filed Apr. 11, 1980, both now abandoned.

This invention relates to the production of butane-1,4-diol.

It has already been proposed to produce butane-1,4-diol by hydroformylation of allyl alcohol using a rhodium complex catalyst thereby to produce 4-hydroxybutyraldehyde (which is in equilibrium with 2-hydroxytetrahydrofuran) followed by hydrogenation. An example of such a proposal will be found in British patent specification No. 1,493,154. Moreover, the hydroformylation of allyl alcohol using a rhodium complex catalyst has been described by several authors (see, for example, C. K. Brown and G. Wilkinson, Tetrahedron Letters, (1969) No. 22, page 1725 et seq and B. Fell and M. Barl, Chemiker-Zeitung, (1977) 101, page 343 et seq.) U.S. Pat. No. 4,064,145 discloses a process for producing tetrahydrofuran by hydroformylation of allyl alcohol using a rhodium complex catalyst followed by aqueous extraction to recover 4-hydroxybutanal and hydrogenation under acidic conditions; a modification is also described for production of butane-1,4-diol by hydrogenation of the 4-hydroxybutanal in the presence of Raney nickel. Hydroformylation of allyl alcohol and subsequent hydrogenation to form butane-1,4-diol is described in United States Defensive Publication No. T 904021. Other references to hydroformylation of allyl alcohol are to be found, for example, in Houben-Weyl, Methoden der Organische Chemie, Vol 6/3 (1965), page 562, in J. Amer. Chem. Soc. Vol. 71 (1949), pages 3051 to 3055, in J. Chem. Soc. (A), (1970), page 2753 to 2764, in U.S. Pat. No. 4,066,705, in West German Offenlegungsschrift No. 2649900, in Japan Kokai 77 78809 (see Chemical Abstracts 87:200776r (1977)), and in Japanese Patent Publication Nos. 53/068715 filed 29th Nov. 1976, 53/068713 filed 30th Nov. 1976, 53/068709 filed 1st Dec. 1976, and 53/071004 filed 3rd Dec. 1976.

It is a drawback of this route to butane-1,4-diol, however, that under the hydroformylation conditions employed allyl alcohol, in addition to forming propanol as a by-product as a result of hydrogenation, undergoes isomerization to propionaldehyde. Moreover the hydroformylation of allyl alcohol appears to be complicated by very ready deactivation of the rhodium complex catalyst possibly induced by by-products of the reaction. Additionally, the desired intermediate 4-hydroxybutyraldehyde tends to undergo internal aldolization spontaneously to form 2-hydroxytetrahydrofuran which is somewhat difficult to convert to butane-1,4-diol by ring opening and reduction. For all of these reasons the production of butane-1,4-diol by a route involving hydroformylation of allyl alcohol is fraught with difficulties.

Accordingly the present invention seeks to provide a process whereby allyl alcohol may be converted to butane-1,4-diol by a process including a hydroformylation step wherein the risk of deactivation of the catalyst due to the deactivating effect experienced in hydroformylation of allyl alcohol is essentially avoided.

The invention further seeks to provide a process for the production of butane-1,4-diol from allyl alcohol which includes a hydroformylation step but which avoids the use of 2-hydroxy-tetrahydrofuran as an intermediate product.

According to the present invention there is provided a process for the production of butane-1,4-diol which comprises reducing an aldehyde-ether of the general formula: ##STR5## wherein R₁ and R₂ each, independently of the other, represent a C₁ to C₄ alkyl radical, and R₃ and R₄ each, independently of the other, represent a hydrogen atom or a C₁ to C₃ alkyl radical, or wherein R₁ represents a C₁ to C₄ alkyl radical, R₂ and R₃ together with the carbon atoms to which they are attached form a 5-membered or 6-membered cycloaliphatic ring, and R₄ represents a hydrogen atom or a C₁ to C₃ alkyl radical to form a hydroxy-ether of the general formula: ##STR6## wherein R₁, R₂, R₃ and R₄ are as defined above, and cleaving resulting hydroxy-ether of the general formula (II) at a temperature of 130° C. or less to give butane-1,4-diol and recovering resulting butane-1,4-diol.

The invention also provides a process for the production of butane-1,4-diol which comprises converting allyl alcohol to an allyl t-alkyl or -cycloalkyl ether of the general formula: ##STR7## wherein R₁ and R₂ each, independently of the other, represent a C₁ to C₄ alkyl radical, and R₃ and R₄ each, independently of the other, represent a hydrogen atom or a C₁ to C₃ alkyl radical, or wherein R₁ represents a C₁ to C₄ alkyl radical, R₂ and R₃ together with the carbon atoms to which they are attached form a 5-membered or 6-membered cycloaliphatic ring, and R₄ represents a hydrogen atom or a C₁ to C₃ alkyl radical, reacting resulting compound of formula (III) under hydroformylation conditions with carbon monoxide and hydrogen in the presence of a hydroformylation catalyst to form an aldehyde-ether of the general formula: ##STR8## wherein R₁, R₂, R₃ and R₄ have the meanings ascribed to them above, reducing resulting aldehyde-ether of the general formula (I) to form a corresponding hydroxy-ether of the general formula: ##STR9## wherein R₁, R₂, R₃ and R₄ have the meanings ascribed to them above, and cleaving resulting hydroxy-ether of the general formula (II) at a temperature of 130° C. or less to give butane-1,4-diol, and recovering resulting butane-1,4-diol.

In the above general formulae (I) to (III) R₁ and R₂ each preferably represent, independently of the other, a methyl or ethyl group, whilst R₃ preferably represents a hydrogen atom or a methyl group and R₄ preferably represents a hydrogen atom. In a particularly preferred process R₁ and R₂ each represent a methyl group and R₃ and R₄ each represent a hydrogen atom.

The production of aldehyde ethers of the general formula (I) is more fully described in our copending application U.S. Ser. No. 139,591, filed simultaneously herewith, the disclosure of which is herein incorporated by reference.

Cleavage of the hydroxy-ether of the general formula (II) yields an olefin of the general formula: ##STR10## wherein R₁, R₂, R₃ and R₄ are as defined above. As examples of olefins of the formula (IV) there can be mentioned iso-butylene, 2-methylbut-1-ene, 2-methylbut-2-ene, 2,3-dimethylbut-2-ene, 3-methylpent-2-ene, 2-ethylbut-1-ene, 1-methylcyclohexene and 1-methylcyclopentene.

Etherification of allyl alcohol can be effected by reaction with an olefin of the general formula (IV), conveniently in the presence of an acidic catalyst. The etherification is a reversible reaction and is favoured by the use of low temperatures, for example a temperature in the range of from about 0° C. to about 80° C. Usually it will be preferred to effect etherification of allyl alcohol at about 60° C. or less, preferably in the range of from about 15° C. to about 60° C. for example in the range of from about 35° C. to about 60° C. Since the olefin may be volatile it may be necessary to effect the etherification reaction under elevated pressure. Typical acidic catalysts for use in the etherification step include ion exchange resins, preferably in anhydrous form, containing sulphonic acid and/or carboxylic acid groups, such as Amberlyst 15 and Dowex 50 resins, as well as aqueous acids, e.g. aqueous solutions of phosphoric acid or dilute aqueous solutions of sulphuric acid (containing, for example, 10% w/v sulphuric acid or less), acid zeolites, acid clays, and organic acids such as p-toluenesulphonic acid or formic acid.

Since a preferred method of converting allyl alcohol to an allyl t-alkyl or -cycloalkyl ether of the general formula (III) comprises reaction of allyl alcohol with an olefin of the general formula (IV) in the presence of an acidic catalyst, the olefin of formula (IV) released upon cleavage of the hydroxy-ether of the general formula (II) can be recycled to the allyl t-alkyl or -cycloalkyl ether formation step.

In the cleavage of the hydroxy-ether of the general formula (II) there may be formed as by-product a tertiary alcohol of the general formula: ##STR11## wherein R₁, R₂, R₃ and R₄ are as defined above. Such an alcohol of the general formula (V) may be dehydrated in the presence of an acidic catalyst to form a corresponding olefin of the general formula (IV) which can be recycled for use in formation of the allyl t-alkyl or -cycloalkyl ether of the general formula (III).

Cleavage of the hydroxy-ether of the general formula (II) can be effected in the presence of a suitable acidic catalyst in the presence of, or in the absence of, an added solvent or diluent. As examples of acidic catalysts for use in ether cleavage there can be mentioned aqueous acids, such as aqueous phosphoric acid or sulphuric acid, as well as acidic ion exchange resins.

Butane-1,4-diol can undergo dehydration and cyclization in the presence of an acidic catalyst, particularly at elevated temperatures, to form thereby tetrahydrofuran. Although tetrahydrofuran is in many instances a valuable by-product of the cleavage step, it will usually be preferred to conduct the cleavage of the hydroxy-ether of the general formula (II) under as mild conditions as possible and to minimise the residence time of product butane-1,4-diol in contact with the acidic catalyst used in the cleavage step. In this way the risk of formation of tetrahydrofuran is minimised and the yield of butane-1,4-diol is maximised. Preferred conditions may include the use of aqueous media and temperatures usually of about 130° C. or less, e.g. in the range of about 80° C. to about 120° C. If severe conditions and/or long residence times are utilised which tend to promote dehydration, or if acidic catalysts which promote dehydration of butane-1,4-diol to tetahydrofuran are selected, then tetrahydrofuran may be formed as the major product in place of butane-1,4-diol. Hence it is preferred to use in the cleavage step conditions (e.g. temperature and residence time) which result in a low conversion to butane-1,4-diol and, after recovery of butane-1,4-diol from the reaction mixture, to recycle unreacted hydroxy-ether of the general formula (II) to the cleavage step. The maximum permissible conversion per pass (and hence the residence time) in the cleavage step will depend inter alia on the activity of the selected catalyst, upon the nature of the groups R₁ to R₄ present, upon the temperature conditions, and upon the nature and quantity of the solvent or diluent used (if any), as well as upon the maximum conversion to tetrahydrofuran that is tolerable for economic or operational reasons. Thus it may be preferred to limit the conversion per pass in the cleavage step to about 50% or less. The catalyst and conditions required to produce an acceptable butane-1,4-diol:tetrahydrofuran product ratio in the cleavage step can readily be determined by a process of "self-directing optimisation" (see Technometrics, November 1962).

In the cleavage step there may be formed as a by-product a diether of the general formula:

    R'--O--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --O--R'   (VI)

wherein R' represents a radical of the general formula ##STR12## wherein R₁, R₂, R₃ and R₄ are as defined above. This can be recycled with advantage to the cleavage step to undergo cleavage itself to form further hydroxy-ether of the general formula (II) and/or butane-1,4-diol and olefin of the general formula (IV).

Recovery of product butane-1,4-diol can be effected in any convenient manner. For example, if cleavage of the hydroxy ether of the general formula (II) is conducted using an acidic ion exchange resin, distillation of the reaction product mixture or water washing can be used. On the other hand, when using an aqueous acid for ether cleavage, the aqueous layer will contain much of the butane-1,4-diol; this can be recovered by neutralization and subsequent distillation, preferably under reduced pressure.

Reduction of the aldehyde ether of the general formula (I) to the hydroxy-ether of the general formula (II) can be effected in any suitable manner, for example, by catalytic hydrogenation under atmospheric, sub-atmospheric or super-atmospheric pressure. Reduction is preferably effected under conditions which are not conducive to ether cleavage. Thus it is preferred to avoid acidic conditions in the reduction step. Raney nickel is a suitable hydrogenation catalyst. Hydrogenation can be effected at ambient, sub-ambient or elevated temperature, e.g. at a temperature in the range of from about 15° C. up to about 120° C. or higher, e.g. up to about 180° C. Other hydrogenation catalysts include commercially available supported metal hydrogenation catalysts, as well as copper chromite and palladium hydrogenation catalysts. Reduction by means of sodium borohydride or lithium aluminum hydride is also feasible.

When using a solid catalyst, such as nickel or other metal on a granular support, a trickle bed system can be used for passing the hydrogen and aldehyde-ether of the formula (I) over the catalyst.

As examples of hydrogenation catalysts there can be mentioned PtO₂, Pd/C, Pt/Al₂ O₃ and commercial catalysts such as Girdler G69 catalyst. Pressures of up to 15 kg/cm² absolute or higher can be used.

In the hydroformylation step, the hydroformylation catalyst may be any Group VIII metal-containing hydroformylation catalyst known to be effective for catalysing the hydroformylation of terminal olefins. Preferably the catalyst is a rhodium-containing catalyst comprising rhodium in complex combination with carbon monoxide and a triorganophosphine ligand, such as triphenylphosphine. When using such a catalyst the concentration of rhodium in the reaction medium may range from about 5 parts per million by weight up to about 1000 parts per million of rhodium or more, calculated as rhodium metal. Typically the rhodium concentration ranges from about 20 parts per million up to about 400 parts per million, e.g. about 40 to about 300 parts per million, calculated as rhodium metal. The reaction medium may contain excess triorganophosphine, e.g. about 2 moles up to about 100 moles or more of excess free triorganophosphine per gram atom of rhodium. Usually the hydrogen:carbon monoxide molar ratio is approximately 1:1, e.g. about 1.05:1. The hydroformylation conditions typically include use of reaction temperatures of from about 20° C. up to about 160° C., e.g. about 70° C. to about 120° C. and use of a partial pressure of hydrogen of from about 0.1 kg/cm² absolute up to about 10 kg/cm² absolute or more and a partial pressure of carbon monoxide of about 0.1 kg/cm² absolute up to about 10 kg/cm² absolute or more. The overall pressure may be about 20 kg/cm² or less. The reaction can be effected in the presence of a solvent, e.g. a mixture of aldehyde condensation products such as is disclosed in British Patent Specification No. 1338237, or in the absence of added solvent. The aldehyde-ether of the general formula (I) can be recovered from the hydroformylation reaction medium by conventional methods, e.g. distillation.

In the hydroformylation step a by-product is the corresponding iso-aldehyde ether of the general formula: ##STR13## wherein R₁, R₂, R₃ and R₄ are as defined above. It may not be necessary to separate this from the aldehyde-ether of the general formula (I) prior to the reduction step, nor to separate the corresponding reduction product, i.e. the iso-hydroxy-ether of the general formula: ##STR14## wherein R₁, R₂, R₃ and R₄ are as defined above, from the hydroxy-ether of the general formula (II), prior to the cleavage step. In this case a by-product of the cleavage step is 2-methylpropane-1,3-diol. Another by-product of the cleavage step may be the corresponding diether of the general formula:

    R'--O--CH.sub.2 --CH(CH.sub.3)--CH.sub.2 --O--R'           (IX)

wherein R' represents a radical of the formula: ##STR15## wherein R₁, R₂, R₃ and R₄ are as defined above. Hence, if no intermediate purification is effect, the cleavage step may yield a complex reaction mixture containing olefin of the general formula (IV), tertiary alcohol of the general formula (V), tetrahydrofuran, unreacted hydroxy-ether of the general formula (II), iso-hydroxy-ether of the general formula (VIII), diethers of the general formulae (VII) and (IX), butane-1,4-diol, 2-methylpropane-1,3-diol, and small amounts of minor by-products, such as complex aldehyde condensation products, (derived from the compounds of the general formulae (I) and (VII)), of the type described in British Patent Specification No. 1338237.

The hydroxy-ethers of the general formulae (II) and (VIII) and the diol-ethers of the general formulae (VI) and (IX) in this mixture can with advantage be recycled to the cleavage step since they can undergo cleavage in a further pass into contact with the acidic catalyst to liberate olefin of the general formula (IV). The complex reaction mixture from the cleavage step can be separated, for example, by distillation into several fractions, possibly in several stages (of which at least one stage may be maintained under reduced pressure). Thus when R₁ and R₂ each represent methyl and R₃ and R₄ each represent a hydrogen atom, a series of five distillation stages can be used, for example, in order to separate components of the crude reaction mixture from the cleavage step. In the first stage of the series iso-butylene is recovered overhead; a mixture of low boiling products including t-butanol and tetrahydrofuran, is taken overhead from a second column of the series. Tetrahydrofuran can be recovered from this mixture by re-distillation. A mixture of hydroxy-ethers of the general formulae (II) and (VIII) and of diol ethers of the general formulae (VII) and (IX) forms an overhead product from a third column which is maintained under vacuum. This mixture can be recycled to the cleavage step. 2-methyl-propane-1,3-diol is removed overhead in a further column (also under vacuum), whilst butane-1,4-diol is recovered overhead in a fifth, vacuum distillation stage of the series; the bottoms products from this fifth column comprises heavy ends, e.g. complex aldehyde condensation products, which can be burnt as a fuel.

The invention is further illustrated by reference to the following Examples.

EXAMPLE 1 A. Preparation of allyl t-butyl ether

50 ml allyl alcohol and 5 g dry Amberlyst 15 resin were placed in a 300 ml capacity autoclave agitated by means of a Magnedrive unit actuating an induction stirrer. (The word "Amberlyst" is a Registered Trade Mark). The autoclave was purged with iso-butylene and then warmed to 30° C. in an oil bath and pressurised to 1.75 kg/cm² absolute with iso-butylene. The pressure dropped as reaction took place and further iso-butylene was introduced to raise the pressure once again to 1.75 kg/cm². This procedure was repeated as necessary until reaction was complete after approximately 90 minutes as indicated by the cessation of uptake of iso-butylene. After releasing the pressure the product was decanted from the resin and washed several times with deionised water. The crude product was subjected to a partial vacuum to remove iso-butylene (until gas chromatography showed that there was less than 0.1% iso-butylene in the product) and then dried over anhydrous sodium carbonate. Gas chromatography, using a gas chromatograph with a flame ionisation detector and temperature programming, indicated that allyl t-butyl ether had been formed with greater than 98% efficiency. The chromatographic column was 1.83 m×3.2 mm O.D. stainless steel, packed with 10% by weight diethylene glycol succinate on Chromosorb W.

B. Hydroformylation of allyl t-butyl ether

The same autoclave was charged with the calculated quantities of HRh(CO)(PPh₃)₃ and PPh₃ and then sufficient Filmer 351 was added to bring the volume of liquid to 90 ml. (Filmer 351 is a complex mixture of polymeric condensation products of n- and iso-butyraldehydes of the type disclosed in British Patent Specification No. 1338237). The autoclave was then sealed. The body of the autoclave was immersed in an oil bath capable of being heated and thermostatically controlled to ±1° C. between 40° C. and 180° C. by means of a heater/stirrer. The pressure within the reactor could be monitored by means of a pressure transducer linked to a single pen recorder. The stirrer was switched on and its speed adjusted to 500 r.p.m. The reactor was purged with a hydrogen/carbon monoxide gas mixture, the composition of which depended on the planned H₂ :CO ratio. The reactor was then pressurised to a level which was 0.35 kg/cm² below the desired operating pressure and isolated. The stirrer speed was then adjusted to 2000 r.p.m. and the temperature increased to the desired value. The pressure was then increased to the required level using the same H₂ /CO mixture and the reactor isolated once more. Subsequently 10 ml of allyl t-butyl ether were pumped into the reactor, whereupon reaction commenced. The rate of reaction was monitored by timing the pressure drop between two defined levels ±0.07 kg/cm² around the design pressure. When the pressure reached the lower defined level, the reactor was repressurised to a level 0.14 kg/cm² above the design operating pressure with an approximately 1:1 H₂ :CO mixture as demanded by the stoichiometric requirements of the reaction and the procedure repeated until the reaction was complete, at which time the rate of pressure drop was negligible. The oil heater/stirrer was then switched off, the hot oil run out of the bath and replaced with cold oil. The oil stirrer was switched on again and the reactor cooled to 40° C. The reactor stirrer was then switched off and the reactor depressurised and opened to permit the reaction solution to be removed for analysis and/or storage.

Analysis of the reaction solution was effected utilising the gas chromatographic method outlined above in Section A. With the aid of an integrator peak areas were computed and from these results molar selectivities were calculated using response factors determined from pure compounds isolated from the reaction solution by preparative chromatography.

The results are set out in the Table.

                                      TABLE                                        __________________________________________________________________________            Partial                                                                        Pressure                                                                Run                                                                               Temp.                                                                              kg/cm.sup.2                                                                           Rh conc.                                                                            TPP conc.                                                                            Reaction Products (yield %)                           No.                                                                               °C.                                                                         CO  H.sub.2                                                                           ppm  wt. % PTBE                                                                               Unknown                                                                              trans-P(=)TBE                                                                          ATBE                                                                               bis-P(=)TBE                                                                           TBMPA                                                                               TBBA                __________________________________________________________________________     1  70  0.53                                                                               0.53                                                                              200  40    0.45                                                                               0.01  3.91    2.88                                                                               1.10   11.11                                                                               80.54               2  50  0.53                                                                               0.53                                                                              1000 10    0.73                                                                               0.41  4.87    --  0.84   17.62                                                                               75.53               3  100 0.53                                                                               0.53                                                                              200  10    1.27                                                                               0.17  29.72   --  7.43    8.75                                                                               52.66               4  70  3.79                                                                               3.79                                                                               50  10    0.86                                                                               0.28  1.05    1.43                                                                               0.35   28.61                                                                               67.42               5  70  0.53                                                                               0.53                                                                              300  20    0.74                                                                               0.33  8.57    trace                                                                              1.93   10.16                                                                               78.27               6  80  2.35                                                                               0.95                                                                              100  20    0.59                                                                               0.19  1.71    1.32                                                                               0.68   21.87                                                                               73.64               __________________________________________________________________________      Note:                                                                          TPP = triphenylphosphine                                                       PTBE = propyl tbutyl ether                                                     transP(=)TBE = transpropen-1-yl tbutyl ether                                   ATBE = allyl tbutyl ether                                                      cisP(=)TBE = cispropen-1-yl tbutyl ether                                        TBMPA = 3t-butoxy-2-methylpropionaldehyde                                     TBBA = 4t-butoxy butyraldehyde                                           

The reaction residues from these and other experiments were combined and subjected to distillation. 4-t-butoxybutyraldehyde was obtained as a colourless liquid.

C. Reduction of 4-t-butoxybutyraldehyde

25 ml 4-t-butoxybutyraldehyde and 2 gms Raney nickel were introduced into a 300 ml stainless steel bomb fitted with a stirrer, which was then sealed, purged first with nitrogen and then with hydrogen, and pressurised with hydrogen to 17.86 kg/cm² absolute. The bomb was then heated to 75° C. and maintained at this temperature. The reactant aldehyde hydrogenated smoothly and virtually quantitatively to 4-t-butoxybutanol. At the completion of the reaction, the bomb was cooled and depressurised and the reaction solution was filtered and analysed using the gas chromatographic technique described above in Section A. The peak ascribed to the starting aldehyde had virtually disappeared and a new peak appeared. The identity of this compound as 4-t-butoxybutan-1-ol was confirmed by conversion to butane-1,4-diol as described below in Section D.

D. Production of butane-1,4-diol

25 ml of a solution containing 1.5 ml 4-t-butoxybutan-1-ol was heated at 100° C. for 2 hours under reflux with 25 ml 10% W/V aqueous phosphoric acid. The solvent in the solution was Filmer 351. Analysis by the gas chromatographic technique described above in Section A showed that cleavage of 4-t-butoxybutanol had proceeded to the extent of about 60%. The product distribution was approximately 93:7 butane-1,4-diol:tetrahydrofuran. t-butanol was detected in the reaction product and some evolution of iso-butylene was also detected during the reaction.

EXAMPLE 2 A. Hydroformylation of allyl t-butyl ether

0.10 gms rhodium hydridocarbonyl tris-(triphenylphosphine), i.e. RhH(CO)(PPh₃)₃, 90 ml allyl t-butyl ether and 10.0 gms triphenylphosphine were charged to a 300 ml autoclave fitted with a magnetically coupled stirrer, a gas inlet dip tube and an outlet valve. The autoclave was sealed, purged with nitrogen whilst stirring its contents, and isolated. Stirring was continued whilst the temperature of the autoclave was raised to 73° C. by immersion in an oil-bath fitted with a thermostatically-controlled heater-stirrer. The autoclave was then purged with a 1:1 molar H₂ :CO mixture and pressurised to 2.1 kg/cm² absolute by closure of the outlet valve. Reaction commenced and proceeded smoothly with a slight exotherm at the beginning of the reaction. As the reaction proceeded, the pressure dropped; when the total pressure reached 1.9 kg/cm² absolute, more 1:1 H₂ :CO mixture was admitted to the autoclave to restore the pressure to 2.1 kg/cm² absolute. This repressurisation technique was repeated as necessary until no more gas was taken up, indicating that reaction was complete. This took between 3 and 4 hours. The autoclave was cooled, depressurised and opened, and the contents discharged and stored under nitrogen.

The resulting solution was analysed by gas chromatography using helium as carrier gas, a column packed with 10% w/w diethylene glycol succinate on Chromosorb PAW and a flame ionization detector. Selectivities were observed as follows:

5.6% to isomerised/hydrogenated allylic feedstock

18.9% to 3-t-butoxy-2-methyl-propionaldehyde (TBMPA)

75.5% to 4-t-butoxybutyraldehyde (TBBA).

These selectivities are expressed in molar percentages.

The two aldehyde-ethers (TBMPA and TBBA) were separated by distillation from the other constituents of the reaction solution and then purified by distillation and characterised by formation of dimedone derivatives and by measurement of physical data. The following results were obtained:

    ______________________________________                                         Property         TBMPA     TBBA                                                ______________________________________                                         Refractive index 1.4128    1.4170                                              (at 23° C.)                                                             Melting point of 107-109° C.                                                                       133-135° C.                                  dimedone derivative                                                            Specific gravity at                                                                             0.849     0.868                                               25° C.                                                                  Boiling Point                                                                  at 743 mm Hg     151.6° C.                                                                         169.5° C.                                    at 760 mm Hg     152.3° C.                                                                         170.5° C.                                    at 100 mm Hg     103.2° C.                                                                         115.6° C.                                    ______________________________________                                    

Nuclear magnetic resonance spectra were obtained for the compounds as follows, using tetramethyl silane as an internal standard and carbon tetrachloride as solvent:

    ______________________________________                                         Identifying letter                                                             of C-atom to which          Chemical shift                                     H-atom is attached                                                                          Nature of peak δ relative to TMS                            ______________________________________                                          ##STR16##                                                                        a             singlet        1.13                                           b triplet        3.31                                                          c triplet of triplets                                                                           2.39                                                          d doublet of triplets                                                                           1.84                                                          e triplet        9.62                                                           ##STR17##                                                                                   a            singlet      1.16                                   b doublet        3.56                                                          c complex multiplet                                                                             2.39                                                          d doublet        1.04                                                          e doublet         9.66.                                                        ______________________________________                                    

In each case the ratios of the peak areas corresponded to the expected ratios as predicted from the respective assigned structural formula. In the case of the doublets, triplets and multiplets the quoted chemical shift is the centred value.

B. Hydrogenation of t-butoxybutyraldehyde

25 ml of reaction solution from Part A of this Example and 1.5 gms Raney nickel were charged to a 300 ml stainless steel bomb fitted with a magnetically coupled stirrer and with inlet and outlet gas lines and valves. The bomb was sealed, purged with hydrogen, whilst stirring its contents, and pressurised to 14.1 kg/cm² absolute with hydrogen. The bomb was then heated to 70° C. in an oil bath, the temperature of which could be varied by means of a thermostatically controlled heater-stirrer. The pressure was maintained at 14.1 kg/cm² absolute by admitting further hydrogen as required. The reactor pressure was controlled using a downstream pressure controller and monitored by means of a pressure transducer linked to a recorder. When no further gas was taken up the bomb was cooled and its contents discharged and filtered. Gas chromatographic analysis, using the technique described in Part A of this Example, indicated that virtually quantitative hydrogenation had occurred. The results obtained were as follows:

    ______________________________________                                                    Reaction Solution                                                                         Hydrogenated                                                        from Part A                                                                               Solution                                                 ______________________________________                                         TBMPA        18.9 mole %  0                                                    TBBA         75.5 mole %  0                                                    3-OH MPTBE   0            18.5 mole %                                          4-OH BTBE    0            74,9 mole %                                          ______________________________________                                          Note:                                                                          3OH MPTBE = 3hydroxy-2-methylpropyl tbutyl ether                               4OH BTBE = 4hydroxybutyl tbutyl ether.                                   

The structures of 3-OH MPTBE and 4-OH BTBE can be assigned to the hydrogenation products by analysis of the cleavage products produced in Part C hereunder.

C. Production of butane-1,4-diol

A further sample of allyl t-butyl ether was hydroformylated by a method analogous to that described in Part A of this Example and a mixture of TBMPA and TBBA separated by distillation from the reaction mixture. This fraction was then hydrogenated by a method similar to that described in Part B of this Example. The resulting hydrogenated mixture had the following analysis as determined by gas chromatography:

46.73 wt% 3-OH MPTBE

51.23 wt% 4-OH BTBE.

7.96 gms of this mixture and 0.2 gms Amberlyst 15 resin were charged to a 50 ml round-bottomed flask provided with a side arm fitted with a septum to facilitate sampling and also provided with a vertical reflux condenser supplied with coolant at -5° C. The top of the condenser was provided with a thermometer and a side arm leading to a Drechsel bottle filled with water. The contents of the flask were stirred magnetically and heated to 115° C. in an oil bath. Gas was evolved and bubbled through the Drechsel bottle and was identified as iso-butylene by gas chromatography, using a diethyl succinate column at 3° C. with helium as carrier gas and using a thermal conductivity detector. Samples were taken through the septum at 30 minute intervals and were analysed by the gas chromatographic technique described above in Part A of this Example.

    ______________________________________                                                Conversion of Selectivity to                                                                            Selectivity to                                 Time   BTBE          THF        BD                                             ______________________________________                                         30 mins                                                                               17.5%         10.7 mole %                                                                               89.3 mole %                                    60 mins                                                                               28.4%         17.1 mole %                                                                               82.8 mole %                                    90 mins                                                                               35.0%         24.1 mole %                                                                               75.9 mole %                                    120 mins                                                                              37.5%         31.0 mole %                                                                               69.0 mole %                                    ______________________________________                                          Notes:                                                                         THF = tetrahydrofuran                                                          BD = butane1,4-diol.                                                     

The identities of tetrahydrofuran and of butane-1,4-diol were confirmed by gas chromatography by comparison with authentic samples. The formation of these compounds confirms the structures assigned to the intermediate aldehyde-ethers formed in Part A of this Example and to the hydroxy-ethers formed in Part B of this Example.

Besides tetrahydrofuran and butane-1,4-diol, the components identified in the reaction mixture included 2-methylpropane-1,3-diol, t-butanol (formed, it is thought, by reaction of iso-butylene with water produced by dehydration of butane-1,4-diol to form tetrahydrofuran), and di-t-butyl ethers of 2-methylpropane-1,3-diol and of butane-1,4-diol (formed, it is thought, by combination of free iso-butylene with 3-OH MPTBE and with 4-OH BTBE respectively).

EXAMPLE 3 A. Preparation of allyl 2-methylbut-2-yl ether

100 gms 2-methylbut-2-ene, 300 gms allyl alcohol and 10 gms Amberlyst 15 resin were charged to a 1-liter flat-bottomed flask containing a magnetic follower and fitted with a stopper incorporating a gas inlet tube dipping below the surface of the liquid in the flask and with an exit tube leading from the gas space to a Drechsel bottle filled with water. The flask was purged with nitrogen and then placed in a water bath at 30° C. on a magnetic stirrer. The contents of the flask were maintained at this temperature for 16 hours and then filtered. After washing 5 times with deionised water, each time at an approximately 1:1 ratio by volume, in order to remove the bulk of the unreacted allyl alcohol, the resulting organic layer was dried over anhydrous sodium carbonate and the ether was purified by distillation. The yield was 137 gms (74.9% based on the olefin), b.p. 125°-127° C. at 770 mm Hg.

B. Hydroformylation of allyl 2 -methylbut-2-yl ether

When 90 ml of allyl 2-methylbut-2-yl ether was used as feedstock, in place of allyl t-butyl ether, in the hydroformylation procedure of Example 2, the following selectivities (expressed in molar percentages) were observed:

7.4% to isomerised/hydrogenated allylic feedstock

19.4% to 3-(2'-methylbutan-2'-oxy)-2-methylpropionaldehyde (MBMPA)

73.2% to 4-(2'-methylbutan-2'-oxy)-butyraldehyde.(MBBA)

C. Hydrogenation of 4-(2'-methylbutan-2'-oxy)butyraldehyde

Using as starting material 25 ml of the reaction solution obtained in Part B of this Example in the procedure of Part B of Example 2 the following selectivities were obtained:

    ______________________________________                                                          Starting                                                                       Material Product                                              ______________________________________                                         3-(2'-methylbutan-2'-oxy)-2-methyl-                                                               19.4 mole %                                                                               0                                                propionaldehyd                                                                 4-(2'-methylbutan-2'-oxy)-                                                                        73.2 mole %                                                                               0                                                butyraldehyde                                                                  3-(2'-methylbutan-2'-oxy)-2-methyl-                                                               0          17.4 mole %                                      propanol                                                                       4-(2'-methylbutan-2'-oxy)-butanol                                                                 0          72.4 mole %                                      ______________________________________                                    

D. Production of butane-1,4-diol

Analysis by gas chromatography of the crude hydrogenated mixture from Part C indicated the following composition:

    ______________________________________                                         3-(2'-methylbutan-2'-oxy)-2-methyl-                                                                     16.25 wt. %                                           propanol                                                                       4-(2'-methylbutan-2'-oxy)-butanol (4-MBOB)                                                               67.6 wt. %                                           ______________________________________                                    

Following the technique described in Part C of Example 2, but using the above crude hydrogenated mixture as starting material, the following results were obtained:

    ______________________________________                                         Time      Conversion of 4-MBOB                                                                           Selectivity to BD                                    ______________________________________                                         30 mins     7%            90.0 mole %                                          60 mins   16.7%           90.4 mole %                                          90 mins   20.7%           90.1 mole %                                          120 mins  25.7%           90.0 mole %                                          ______________________________________                                    

No gas was evolved from the condenser, the olefin (2-methylbut-2-ene) being retained in the reaction vessel. As before 2-methylpropane-1,3-diol was detected in the reaction mixture, together with traces of materials believed to be diethers of butane-1,4-diol and 2-methylpropane-1,3-diol of the general formula (VI).

EXAMPLE 4 A. Preparation of allyl 2,3-dimethylbut-2-yl ether

The procedure of Part A of Example 3 was repeated utilising 100 gms of 2,3-dimethylbut-2-ene in place of the 100 grms of 2-methylbut-2-ene. This resulted in a yield of 88 gms of allyl 2,3-dimethylbut-2-yl ether (52.1% based on the olefin), b.p. 144°-147° C. at 765 mm Hg.

B. Hydroformylation of allyl 2,3-dimethylbut-2-yl ether

The hydroformylation procedure of Example 2 was repeated utilising 90 ml of allyl 2,3-dimethylbut-2-yl ether in place of allyl t-butyl ether. The selectivities achieved (expressed in molar percentages) were as follows:

6.0% to isomerised/hydrogenated allylic feedstock

19.3% to 3-(2',3'-dimethylbutan-2'-oxy)-2-methylpropionaldehyde

74.7% to 4-(2',3'-dimethylbutan-2'-oxy)-butyraldehyde.

C. Hydrogenation of 4-(2',3'-dimethylbutan-2'-oxy)-butyraldehyde

Using as starting material in the procedure of Part B of Example 2 25 ml of the reaction solution obtained in Part B of this Example the following selectivities were obtained:

    ______________________________________                                                          Starting                                                                       Material Product                                              ______________________________________                                         3-(2'-3'-dimethylbutan-2'-oxy)-2-                                                                 19.3 mole %                                                                               0                                                methyl-propionaldehyde                                                         4-(2',3'-dimethylbutan-2'-oxy)-                                                                   74.7 mole %                                                                               0                                                butyraldehyde                                                                  3-(2',3'-dimethylbutan-2'-oxy)-2-                                                                 0          17.2 mole %                                      methyl-propanol                                                                4-(2',3'-dimethylbutan-2'-oxy)-                                                                   0          72.4 mole %                                      butanol                                                                        ______________________________________                                    

D. Production of butane-1,4-diol

Analysis by gas chromatography of the crude hydrogenated mixture from Part C indicated the following composition:

    ______________________________________                                         3-(2',3'-dimethylbutan-2'-oxy)-2-methyl-                                                              15.5 wt. %                                              propanol                                                                       4-(2',3'-dimethylbutan-2'-oxy)-butanol                                                                65.1 wt. %                                              (4-DiMBOB)                                                                     ______________________________________                                    

Using the technique described in Part C of Example 2, but with the above hydrogenated mixture as starting material, the following results were obtained:

    ______________________________________                                         Time     Conversion of 4-DiMBOB                                                                          Selectivity to BD                                    ______________________________________                                         30 mins  21.6%            93.2 mole %                                          60 mins  33.6%            92.0 mole %                                          90 mins  43.4%            90.4 mole %                                          120 mins 48.9%            90.8 mole %                                          ______________________________________                                    

The production of olefin and formation of by-products followed a similar pattern to that observed in Part D of Example 3.

EXAMPLE 5 A. Preparation of allyl 1-methylcyclohexyl ether

The procedure of Part A of Example 3 was repeated using 100 gms of 1-methylcyclohexene as the olefin in place of iso-butylene. The yield of allyl 1-methylcyclohexyl ether was 93.5 gms (58.3% based on the olefin), b.p. 138°-140° C. at 240 mm Hg.

B. Hydroformylation of allyl 1-methycyclohexyl ether

When 90 ml of allyl 1-methylcyclohexyl ether was utilised as feedstock in the hydroformylation procedure of Example 2 the selectivites (expressed in molar percentages) were as follows:

8.0% to isomerised/hydrogenated allylic feedstock

19.0% to 3-(1'-methylcyclohexanoxy)-2-methylpropionaldehyde

73.0% 4-(1'-methylcyclohexanoxy)-butyraldehyde.

C. Hydrogenation of 4-(1'-methylcyclohexanoxy)-butyraldehyde

Using as starting material in the procedure of Part B of Example 2 25 ml of the reaction solution obtained in Part B of this Example the following results were obtained:

    ______________________________________                                                        Starting Material                                                                         Product                                              ______________________________________                                         3-(1'-methylcyclohexanoxy)-2-                                                                   19.0 mole %  0                                                methyl-propionaldehyde                                                         4-(1'-methylcyclohexanoxy)-                                                                     73.0 mole %  0                                                butyraldehyde                                                                  3-(1'-methylcyclohexanoxy)-2-                                                                   0            19.7 mole %                                      methyl-propanol                                                                4-(1'-methylcyclohexanoxy)-                                                                     0            73.0 mole %                                      butanol (4-MCHB)                                                               ______________________________________                                    

D. Production of butane-1,4-diol

Analysis by gas chromatography of the crude hydrogenated mixture from Part C indicated the following composition:

    ______________________________________                                         3-(1'-methylcyclohexanoxy)-2-methyl-                                                                 17.7 wt. %                                               propanol                                                                       4-(1'-methylcyclohexanoxy)-butanol                                                                   65.7 wt. %                                               (4-MCHB)                                                                       ______________________________________                                    

Using the technique described in Part C of Example 2, but with the above hydrogenated mixture as starting material, the following result was obtained:

    ______________________________________                                         Time     Conversion of 4-MCHB                                                                           Selectivity BD                                        ______________________________________                                         30 mins  15.2%           88.2%                                                 ______________________________________                                    

The production of olefin and formation of by-products followed a similar pattern to that observed in Part D of Example 3.

EXAMPLE 6

The procedure of Part C of Example 2 is repeated on a larger scale and the iso-butylene is collected in a receiver cooled in "dry ice"/iso-propanol and then used to form a further amount of allyl t-butyl ether. After purification, this is hydroformylated by the procedure described in Part A of Example 2, thus demonstrating that an olefin of the general formula (IV) formed by cleavage of a hydroxy ether of the general formula (II) can be recycled to the step of forming an allyl ether of the general formula(III).

EXAMPLE 7

The same autoclave as was used in Example 2 was charged with the following components:

    ______________________________________                                         Component        Amount                                                        ______________________________________                                         HRh(Co)(PPh.sub.3).sub.3                                                                        0.1        gms                                                PPh.sub.3        10         gms                                                Allyl t-butyl ether                                                                             90         ml                                                 ______________________________________                                    

Using the procedure described in Section A of Example 2, the course of the reaction was monitored at 73° C. using a 1:1 H₂ :CO mixture at a total pressure of 4.22 kg/cm² absolute. Analysis of the reaction solution when gas uptake ceased indicated that substantially all of the allyl t-butyl ether had reacted.

In contrast, on replacing the 90 ml of allyl t-butyl ether with 90 ml of allyl alcohol, the reaction proceeded to only 36% conversion before gas uptake effectively ceased indicating that essentially total deactivation of the catalyst had occurred. 

We claim:
 1. A process for the production of butane-1,4 diol which comprises reducing an aldehyde-ether of the general formula: ##STR18## wherein R₁ and R₂ each, independently of the other, represent a C₁ to C₄ alkyl radical, and R₃ and R₄ each, independently of the other, represent a hydrogen atom or a C₁ to C₃ alkyl radical, or wherein R₁ represents a C₁ to C₄ alkyl radical, R₂ and R₃ together with the carbon atoms to which they are attached form a 5-membered or 6-membered cycloaliphatic ring, and R₄ represents a hydrogen atom or a C₁ to C₃ alkyl radical, to form a hydroxy ether of the general formula: ##STR19## wherein R₁, R₂, R₃ and R₄ are as defined above, cleaving resulting hydroxy-ether of the general formula (II) at a temperature of 130° C. or less to give butane-1,4-diol, and recovering resulting butane-1,4-diol.
 2. A process according to claim 1, in which the aldehyde-ether of the general formula (I) is produced by reaction of an allyl t-alkyl or -cycloalkyl ether of the general formula: ##STR20## wherein R₁, R₂, R₃ and R₄ have the meanings ascribed to them in claim 1, under hydroformylation conditions with carbon monoxide and hydrogen in the presence of a hydroformylation catalyst.
 3. A process according to claim 2, in which the ether of the general formula (III) is produced by reaction of allyl alcohol with an olefin of the general formula: ##STR21## wherein R₁, R₂, R₃ and R₄ have the meanings ascribed to them in claim
 1. 4. A process according to claim 1, in which cleavage of the hydroxy ether of the general formula (II) is effected in the presence of an acidic catalyst.
 5. A process according to claim 4, in which the acidic catalyst is selected from aqueous acids and acidic ion exchange resins.
 6. A process according to claim 1, in which R₁ and R₂ each represent, independently of the other, a methyl or ethyl group, R₃ represents a hydrogen atom or a methyl group and R₄ represents a hydrogen atom.
 7. A process for the production of butane-1,4-diol which comprises converting allyl alcohol to an allyl t-alkyl or cycloalkyl ether of the general formula: ##STR22## wherein R₁ and R₂ each, independently of the other, represent a C₁ to C₄ alkyl radical, and R₃ and R₄ each, independently of the other, represent a hydrogen atom or a C₁ to C₃ alkyl radical, or wherein R₁ represents a C₁ to C₄ alkyl radical, R₂ and R₃ together with the carbon atoms to which they are attached form a 5-membered or 6-membered cycloaliphatic ring, and R₄ represents a hydrogen atom or a C₁ to C₃ alkyl radical, reacting resulting compound of formula (III) under hydroformylation conditions with carbon monoxide and hydrogen in the presence of a hydroformylation catalyst to form an aldehyde-ether of the general formula: ##STR23## wherein R₁, R₂, R₃ and R₄ have the meanings ascribed to them above, reducing resulting aldehyde ether of the general formula (I) to form a hydroxy-ether of the general formula: ##STR24## wherein R₁, R₂, R₃, and R₄ have the meanings ascribed to them above, cleaving resulting hydroxy-ether of the general formula (II) at a temperature of 130° C. or less to give butane-1,4-diol, and recovering resulting butane-1,4-diol.
 8. A process according to claim 7, in which the ether of the general formula (III) is produced by reaction of allyl alcohol with an olefin of the general formula: ##STR25## wherein R₁, R₂, R₃ and R₄ have the meanings ascribed to them in claim 7, and in which olefin of the general formula (IV) released upon cleavage of the hydroxy-ether of the general formula (II) is recycled for reaction with further allyl alcohol to produce a further quantity of the ether of the general formula (III).
 9. A process according to claim 7, in which cleavage of the hydroxy-ether of the general formula (II) is carried out to partial conversion only and in which unreacted hydroxy-ether of the general formula (II) is recovered and recycled to the cleavage step.
 10. A process according to claim 7, in which diether of the general formula:

    R'--O--CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --O--R'   (VI)

wherein R' represents a radical of the general formula ##STR26## wherein R₁, R₂, R₃ and R₄ are as defined in claim 7, formed as by-product in the cleavage of the hydroxy-ether of the general formula (II) is recycled to the cleavage step. 